2010 Nov;29(8):1445-50. doi: 10.1002/nau.20886. If you have reduced liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

www.medbroadcast.com/drug/getdrug/Platinum-Muscle-and-Back-Pain-Relief, are allergic to methocarbamol, ibuprofen, or any ingredients of the medication, are allergic to other carbamates, or nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., naproxen, ketoprofen, diclofenac), are also taking other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., naproxen, ketoprofen, diclofenac), are going to or have just had heart surgery, are 12 years of age or older and have kidney disease with significant fluid loss (dehydration) due to vomiting, diarrhea, or the lack of fluid intake, have an active stomach ulcer or duodenal ulcer, or a history of recurrent stomach or duodenal ulcers, have active inflammatory gastrointestinal (stomach and intestine) disease (e.g., diverticulosis, ulcerative colitis, Crohn's disease), have active liver disease or poor liver function, have asthma, anaphylaxis, hives, rhinitis, or other allergic reactions that are caused by acetylsalicylic acid (ASA) or other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., naproxen, ketoprofen, diclofenac), signs of bleeding (e.g., unusual bleeding or bruising, bleeding gums, unexplained nosebleeds), sudden, large increase or decrease in the amount of urine, signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds), signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, difficulty breathing), signs of meningitis not caused by infection (e.g., headache (severe), throbbing, or with stiff neck or back, decreased level of consciousness). Selected from data included with permission and copyrighted by First Databank, Inc. Limit alcoholic beverages. The recommended dose for adults and children over 12 years of age is 1 or 2 caplets every 4 to 6 hours. Acetazolamide may increase the excretion rate of Phenazopyridine which could result in a lower serum level and potentially a reduction in efficacy. Do not take a double dose to make up for a missed one. Do not use in larger or smaller amounts or for longer than recommended. Although there is no specific information comparing use of phenazopyridine in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults. Store at room temperature away from light and moisture. If your doctor has told you to take this medication on a regular basis and you miss a dose, take it as soon as possible and continue with your regular schedule. Do not use phenazopyridine for longer than 2 days unless your doctor has told you to.

rhabdomyolysis effects Drug interactions may change how your medications work or increase your risk for serious side effects. Call your doctor for medical advice about side effects. Systemic lupus erythematosus (SLE):People with SLE appear to be at a greater risk of experiencing severe adverse reactions to ibuprofen, including anaphylaxis. 1998-2022 Mayo Foundation for Medical Education and Research (MFMER).

The usual dose is 4 mg per kilogram (kg) (about 1.8 mg per pound) of body weight three times a day. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Pediatr Nephrol. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs.

[, Rehfuss A, Mahon J, Sorokin I, Smith C, Stein BS: Phenazopyridine: A Preoperative Way to Identify Ureteral Orifices. For relieving pain, burning, and discomfort in the urinary tract: Adults and teenagers200 milligrams (mg) three times a day. If you have bleeding disorders, a history of bleeding problems, or are taking medications to prevent clotting, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. It is not known whether phenazopyridine passes into breast milk or if it could harm a nursing baby. It relieves urinary urgency frequency, burning, pain, and discomfort.14,18, A note on urine and skin discoloration and interference with test results, Yellowing of the skin or sclerae of the eyes may indicate that the accumulation of phenazopyridine has occurred. https://www.mayoclinic.org/drugs-supplements/phenazopyridine-oral-route/side-effects/drg-20065473, Advertising and sponsorship opportunities, Glucose-6-phosphate dehydrogenase (G6PD) deficiency or.

Aseptic meningitis:Some NSAIDs such as ibuprofen can cause symptoms of aseptic meningitis (e.g., stiff neck, severe headache, nausea, vomiting, fever, decreased level of consciousness). Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Urine and tears will return to normal color after the medication is stopped. An infection may require additional medicine. Also, the medicine may stain clothing. Does Urinary Pain Relief interact with other drugs you are taking? signs of a serious allergic reaction, e.g.

This information should not be interpreted without the help of a healthcare provider.

Phenazopyridine is a dye that works as a painkiller to soothe the lining of the urinary tract. If you are a breast-feeding mother and are taking methocarbamol - ibuprofen, it may affect your baby. When a large overdose occurs, methemoglobinemia results.5,6 To treat this condition, Methylene blue at 1 to 2 mg/kg/dose should be administered intravenously as a 1% solution as deemed necessary. The absence of an interaction does not necessarily mean no interactions exist. What form(s) does this medication come in? Phenazopyridine can interfere with certain laboratory tests (including urine tests for kidney function, bilirubin, and sugar levels), possibly causing false test results. Build, train, & validate predictive machine-learning models with structured datasets.

Canada residents can call a provincial poison control center. Inform your doctor if your condition lasts or gets worse. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. [, Thomas BH, Whitehouse LW, Solomonraj G, Paul CJ: Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs.

What will it do for me? Your pharmacist may be able to advise you on managing side effects. UseUrinary Pain Relief Maximum Strength (Oral)exactly as directed on the label, or as prescribed by your doctor. If you have had a heart attack or stroke, or are at risk of a heart attack or stroke, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Phenazopyridine. What side effects are possible with this medication? These side effects may go away during treatment as your body adjusts to the medicine.

Side effects can be mild or severe, temporary or permanent.

Drowsiness/reduced alertness:This medication may cause drowsiness. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. [Webinar] Discover how academic researchers use, Signs or symptoms of urinary tract irritation, Sodium channel protein type 1 subunit alpha, G GENITO URINARY SYSTEM AND SEX HORMONES, Propargyl-type 1,3-dipolar organic compounds, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), splash10-03di-3790000000-b512b9204606a7555a5b, splash10-03di-2970000000-0b1e342d0932d1b1e514, splash10-05fr-4900000000-ca0b4addc8cef352136e, splash10-053r-9600000000-3269efb012d6f568ca89, splash10-003r-9100000000-82c1432637ce4b1cf4f4, splash10-05vk-3920000000-53a0d95ed732abd389e7. Hemolytic anemia is also a risk when an overdose occurs, and bite cells may be observed in a blood smear after an overdose with phenazopyridine. [, Murphy T, Fernandez M: Acquired methemoglobinemia from phenazopyridine use. The risk or severity of nephrotoxicity can be increased when Phenazopyridine is combined with Acemetacin.

This medication may be available under multiple brand names and/or in several different forms. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. This document does not contain all possible drug interactions. Nephrotoxicity, renal failure, and hepatic impairment may also occur in a case of overdose with this drug. Skip the missed dose if it is almost time for your next scheduled dose. Breast-feeding:Ibuprofen passes into breast milk. The contents herein are for informational purposes only. Phenazopyridine is used to treat urinary symptoms such as pain or burning, increased urination, and increased urge to urinate. Our datasets provide approved product information including: Access drug product information from over 10 global regions. Alcohol or marijuana (cannabis) can make you more dizzy. Many of these side effects can be managed, and some may go away on their own over time. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. 2005 - 2022 WebMD LLC.

Phenazopyridine Plus 150-15-0.3 mg tablet, CVS Pharmacy urinary pain rlf 95 mg tablet, https://www.lookchem.com/Phenazopyridine-hydrochloride/, https://pdfs.semanticscholar.org/182c/23f8f9a5935f172b01241dd7c06d8d72b6f3.pdf, https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phenazopyridine, Shore SN, Britnell SR, Brown JN: Safety analysis of long-term phenazopyridine use for radiation cystitis.

2006 Nov;21(11):1760-4. doi: 10.1007/s00467-006-0196-1. This medicine may cause false test results with urine sugar tests and urine ketone tests. The following side effects have been reported by at least 1% of people taking this medication.

ChildrenThe dose is based on body weight and must be determined by your doctor.

Copyright 2022 IBM Watson Health. [, Thomas BH, Whitehouse LW, Solomonraj G, Paul CJ: Metabolism and disposition of phenazopyridine in rat. In the USA, this drug was previously marked by Roche but has been discontinued by the FDA.16 It is still used in various parts of the world. The mean elimination half-life of phenazopyridine is 7.35 hours in rats with healthy renal function.12 The half-life in man is not readily vailable in the literature. If you experience symptoms of an infection (e.g., fever, sore throat), contact your doctor as soon as possible. Do not use this medication while wearing soft contact lenses. Phenazopyridine will most likely darken the color of your urine to an orange or red color. It can be harmful for people to take this medication if their doctor has not recommended it. If you have any questions about this, check with your health care professional, especially if your diabetes is not well controlled. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. It is usedto relieve pain associated with muscle spasmsuch as strains and sprains, back pain, and tense neck muscles.

How does this medication work? 2003 Aug;25(2):143-8. Otherwise, call a poison control center right away. Check with your doctor as soon as possible if any of the following side effects occur: Stop taking the medication and seek immediate medical attention ifanyof the following occur: Some people may experience side effects other than those listed.

This medication can cause unusual results with urine tests. If you become pregnant while taking this medication, contact your doctor immediately.

Each white and blue, biconvex, bilayered film-coated caplet debossed with "IM" on one side and plain on the other side contains 500mg of methocarbamol (blue) and 200mg of ibuprofen (white). Source: www.medbroadcast.com/drug/getdrug/Platinum-Muscle-and-Back-Pain-Relief, 02361922 Platinum Muscle and Back Pain Relief Tablet. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. This dye accumulates in the skin, and yellow skin pigmentation has been observed when high doses of this drug have been taken.14 Triaminopyridine is also a metabolite of phenazopyridine.22 During a pharmacokinetic study, aniline contributed to approximately 6.9% of urinary metabolites. Should I avoid certain foods while taking Urinary Pain Relief?

This may stain clothing and contact lenses. Drink plenty of liquids while you are taking phenazopyridine. Do not share this medication with others. Although there is no specific information comparing use of phenazopyridine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults. If you experience symptoms of liver problems such as fatigue, nausea, vomiting, stomach pain, yellowing of the skin or eyes, pale stools, dark urine, stop taking this medication and contact your doctor. This survey is being conducted by the WebMD marketing sciences department. [, Onder AM, Espinoza V, Berho ME, Chandar J, Zilleruelo G, Abitbol C: Acute renal failure due to phenazopyridine (Pyridium) overdose: case report and review of the literature. People who have experienced difficulty breathing after taking ASA or other NSAIDs should not take methocarbamol - ibuprofen. Blood pressure:Ibuprofen may cause an increase in blood pressure, even when there have been no blood pressure problems in the past. Do not use this medicine without a doctor's advice if you are pregnant.

Phenazopyridine can dye your urine and tears orange-red. This effect is harmless and will go away after you stop taking the medicine. Store this medication at room temperature, protect it from light, and keep it out of the reach of children. You should not use phenazopyridine if you are allergic to it, or if you have kidney disease.

Along with its needed effects, a medicine may cause some unwanted effects. To make sure phenazopyridine is safe for you, tell your doctor if you have: FDA pregnancy category B. Phenazopyridine is not expected to harm an unborn baby. Use exactly as directed on the label, or as prescribed by your doctor. Many medicines have not been studied specifically in older people. This is a normal effect and is not harmful. 1996-2022 Everyday Health, Inc. Phenazopyridine may decrease the excretion rate of Acrivastine which could result in a higher serum level. change one of the medications to another, change how you are taking one or both of the medications, or. For non-prescription products, read the label or package ingredients carefully. [, Gold NA, Bithoney WG: Methemoglobinemia due to ingestion of at most three pills of pyridium in a 2-year-old: case report and review. All rights reserved. If you believe you are experiencing an interaction, contact a healthcare provider immediately. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. You may report side effects to FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects. Take your next dose at the regular time. It contributes to the relief of discomfort and pain before antimicrobial therapy begins to take effect. As well, some forms of this medication may not be used for all of the conditions discussed here. Phenazopyridine causes the urine to turn reddish orange . Report any ongoing increase in blood pressure to your doctor as soon as possible. Contact your doctor if you experience these side effects and they are severe or bothersome. Store at room temperature away from moisture and heat. Epub 2006 Aug 1. Speak to your doctor about how any drug interactions are being managed or should be managed.

Red blood cell G6PD deficiency may increase the risk of hemolysis, and even normal doses can lead to methemoglobinemia in patients with this condition. Do not double doses. Also tell them about any supplements you take. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you have an autoimmune disorder, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Talk to your pharmacist for more details. Before you take methocarbamol - ibuprofen, inform your doctor about any previous adverse reactions you have had to medications, especially NSAIDs. shortness of breath, tightness in chest, wheezing, or troubled breathing, swelling of face, fingers, feet, and/or lower legs. Check with your doctor if symptoms such as bloody urine, difficult or painful urination, frequent urge to urinate, or sudden decrease in the amount of urine appear or become worse while you are taking this medicine . The risk or severity of nephrotoxicity can be increased when Phenazopyridine is combined with Aceclofenac. confusion, loss of appetite, pain in your side or lower back; fever, pale or yellowed skin, stomach pain, nausea and vomiting; or.

Do not take methocarbamol - ibuprofen if you: Many medications can cause side effects. Portions of this document last updated: Feb. 01, 2022, Original article: https://www.mayoclinic.org/drugs-supplements/phenazopyridine-oral-route/side-effects/drg-20065473. Bladder problems:NSAIDs such as ibuprofen can cause bladder problems. Keep all medications away from children and pets. [, UPMC: Final Diagnosis -- Suicide Attempt with Ingestion of Pyridium Tablets [, Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids [, Murfreesboro Pharmaceutical Nursing Supply. Does Urinary Pain Relief interact with other medications? Phenazopyridine may cause discoloration or staining of contact lenses.

Phenazopyridine may decrease the excretion rate of Abacavir which could result in a higher serum level. Tell your doctor if you are pregnant before using this medication.

Blurred vision:If you experience blurred vision while taking this medication, stop taking it and contact your doctor. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

The irritation may be a result of trauma, surgery, endoscopic procedures, infection, or the insertion of instruments or urinary catheters.14 Phenazopyridine may be used in combination with antimicrobial therapy but is not used as an antimicrobial agent. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

Tell your doctor right away if you have any serious side effects, including: yellowing skin/eyes, dark urine, signs of kidney problems (such as change in the amount of urine, bloody urine), stomach/abdominal pain, vomiting, fever, chills, easy bruising/bleeding, unusual tiredness, shortness of breath, fast heartbeat, seizures. Fluid retention and high potassium levels:NSAIDs such as ibuprofen can cause fluid retention and high blood potassium levels.

Use our structured and evidence-based datasets to unlock new insights and accelerate drug research. 2019 Apr 22:1078155219842646. doi: 10.1177/1078155219842646.

A single copy of these materials may be reprinted for noncommercial personal use only. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Phenazopyridine is a pain reliever that affects the lower part of your urinary tract (bladder and urethra). Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here.

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