The set-up allows us to further advance our research in both continuous flow and droplet microfluidics.. Each channel can be controlled independently and deliver a specific amount of pressure or vacuum to handle fluids. Point of care tests such as blood analysis, glucose monitoring, infectious disease testing, cholesterol testing, or cardiac markers are marketed1. Two pressure modules consisting of a 0 2000 mbar and -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Combine as many modules as you want to fit your application needs. The MFCS can be controlled by Fluigent software to automate your protocols. The Push-Pull allows for regulatation of pressure and vacuum down to -800 mbar and up to 1 bar from one single channel. Front. evaluate fluigent Mixed pressure ranges can be connected to the same board (positive and negative pressures, and Push-Pull). All-in-one pressure controller and supply powered by battery or line voltage. The pressure automatically adjusts in the background to maintain the set flow rate. This system can be integrated, automated or control in real time by using Fluigent Software Solutions. The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. The technology is powered by an embedded rechargeable battery to facilitate portability. Janire, S., Raquel, C.-C., R_oisn, M. O. The pressure automatically adjusts in the background to maintain the set flow rate. Combine up to 12 modules as your work flow grows. The technology consists of a uniquely engineered assembly of electronics, sensors integrated with a micropump, and pneumatics to provide high performance. Valve and switch platform for directing the fluid flow, including bidirectional and rotary multi-port port valves. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, Things you should know when integrating fluidics into your system, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, Droplet generation using syringe pumps and pressure-based flow controllers, Extended capabilities of pressure driven flow for microfluidics applications, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, Pressure predictions for lab-on-a-chip operations using a microfluidic network solver and Fluigent PX, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Control in real-time, protocol automation, data record and export. 6). This allows the user to set a flow rate directly on the instrument display. Liquid flow rate ranges from a few nL/min to 5 mL/min. The PX Pressure-driven flow control simplifies fluid management even for multiple fluids, and reduces the time needed to add or remove channels. The PRESSURE UNIT product line allow for the accurate measurement of pressure and vaccum within the range -1000 mbar to 7 bar.

When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. The device is well designed and allows for easy control of my microfluidic chips. It can support a wide range of connections (Wi-Fi, BLE, IoT, USB, industrial bus), and embedded protocols. Control without a PC using the Push-Pull hardware interface with one hand. fluigent The MFCS is a pressure based microfluidic flow controller. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. The applied pressure will automatically adjust to maintain the flow rate. Each P-SWITCH module requires 2 supplied sources overthe range or -800 mbar to 2 bar. A switch module is also directly connected to the F-OEM main board, allowing for connecting a bidirectional 11-port / 10-way microfluidic valve for injection or selection of up to 10 different fluids (Fluigent M-X). The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. The Flow EZ can maintain continuous, pulseless flow for days without refilling. Flow-rates can be monitored or controlled using Fluigent DFC self-learning flow rate control algorithm. Customize your own controller to answer your control needs. The MFCS-EX provides up to 8 negative or positive pressure channels to pressurize multiple fluid reservoirs. To ensure excellent response time while guaranteeing the best performance, Fluigent developed a technology that makes use of proportional valves. When connected to a computer, one can use our Fluigent software tobenefit from automationorlive monitoring and recording of data. Fluigent was the first company to solve this problem by introducing an innovative technology: pressure pumps. Fluigent industrial builds on our 15 years of pressure-based flow control expertise and proprietary technologies to bring versatile, cost-effective, and customizable OEM products and systems. These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. No microfluidic valves. The algorithm includes a continuous optimization of the parameters that allow it to adapt to the interactions between microfluidic channels in complex situations. & Lourdes, Basabe-Desmonts Fernando, B.-L. Microfluidics and materials for smart water monitoring: A review. The FASTAB microfluidic patented technology used by MFCS series avoids cross contamination as there is no direct contact between the instrument and the reagents. It is well established that pressure-based flow control offers unequaled flow stability and response times. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. Its improved reactivity allows countering, in real-time, the interactions between microfluidic channels in complex situations. Benefit from the best performance and Fluigent expertise for your project. Our engineered systems tackle these limitations by bringing a cost-effective solution with a highly reduced footprint. These often require more bulky equipment as the internal technology is more advanced. These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. What I like most is that you are independent of a computer and can directly control both positive and negative pressure.. The MFCSTM series and Flow EZTM with Fluigent valves can be used for automated cell perfusion as in the next video. Whether your application is with droplets, cell biology, particle studies, or in other research areas, we have the expertise and knowledge to provide the most cost-effective and technically advanced solutions for your fluid control needs. The sensor can be directly connected to a PC via USB, and display measurement in real time onthe Fluigent OxyGENsoftware interface. When combined with theLINKmodule, thePush-Pullcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). 8, 114 (2021). The Push-Pull can maintain continuous, pulseless flow for days without refilling. When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. The applied pressure will automatically adjust to maintain the flow rate. The P-SWITCH allows to multiply the outlets of the system and the SWITCH EZ controls microfluidic valves. Reach your pressure targets rapidly and get your experiment started instantaneously. The principle of pressure actuation in microfluidic systems is shown in the figure.

In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. Continuous monitoring of water resources such as freshwater, seawater, and, in particular, wastewater and drinking water, for human and animal consumption, is essential2. The Adapt is used to connect Flow EZ modules with different pressure ranges without the need of additional pressure sources. Supports both pressure control and direct volume flow rate control depending on user needs. A new generation of point of care diagnostic devices has been recently developed for providing higher sensitivity diagnostics, such as nucleic acid amplification tests. The Flow EZ integrates the all-new DFC (Direct Flow Control) algorithm. It is available for vacuum and pressures of up to 2 bar. 3 pressure modules consisting of two 0 2000 mbar and a -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. Complex pressure and flow distribution can be eliminated as the unit can be placed at the location where pressure, vacuum, or flow control is needed. Using a pressure leakage or a valve in complement to the pump is a way to circumvent this limitation. As an alternative, microfluidic-based portable devices have been developed for on-site analysis. Support reservoir sizes from 2 mL to one liter laboratory bottles. Fluigent pressure and flow controllers bring this performance and benefits to the system. See an example of applications using the MFCS series: Separation of parasites from human blood using deterministic lateral displacement, S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Lab Chip, vol.11, 2011. We have a large range of flow sensors ranging from 0-1.5 L/min to 0-5 mL/min. 2. Improved reliability and reproducibility of of results is possible due to the pulseless flow. A pneumatic path combined with Fluigents regulation algorithm has been developed to deliver regulated pressure from a pressure source.

1. We offer modern microfluidic systems and components that enhance productivity. Flow sensors are connected for flow rate monitoring and control. With the addition of a pressure leakage component, the pressure drop now takes about 5 seconds (see Fig. Plug directly the sensor to the PC and benefit from a compact solution for pressure detection. Using this engineered solution, pressure drop takes less than a second, and the maximum pressure reachable has not deteriorated (see graph). TheFlow EZis the most advanced system available forpressure-based flow control.

The pulseless and precise control enabled by our pressure-driven technology is critical for repeatable results in many applications. Inject and switch different flow paths. Configuration 2: 2 pressure modules 2 flow sensors. The technology used in this pressure pumpavoids cross-contaminationbecause liquids only contact air. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. In fact, it is possible to observe that the micropump will take more than a minute to reach zero pressure. Along with the MCFS-EZ or MCFS-EX, a Manifold can be added to redirect the pressure to multiple fluid reservoirs.

Fluigent is an international company which develops, manufactures and supports the most advanced fluid control systems available for microfluidics offering greater control, automation, precision, and ease of use.. https://cordis.europa.eu/article/id/421573-microfluidics-is-the-future-of-agriculture-with-on-site-soil-analysis, Development of complete device based on your needs, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, (Patent pending) compact all-in-one pressure supply & pressure/flow control, Things you should know when integrating fluidics into your system, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, All in one micropump for pressure source and control, Need to be connected to an external pressure source and power supply, Pressure: Up to 600 mbar (for a single pump), No overshoot/undershoot, allowing for an immediate highly accurate and stable flow, Useful over a wide pressure or vacuum range (up to 600 mbar, -400 mbar vacuum, standalone pressure/vacuum regulation capability). is well-suited technology for applications that require mobile or compact fluidic control devices, including point of care (PoC) diagnostic and testing, or for water and soil on-site analysis. Emerging point of care applications make use of more complex fluidic operations and require compact systems. The FLUIGENT PX pressure controller is a single, miniaturized electronic pressure controller with an integrated and intelligent feedback loop for highest performance. The entire system can be controlled without a PC using local control and can also be monitored by Fluigent Software to extend its capabilities and benefit from automation. Custom software application: Public SDK libraries are available on GitHub for all integration into the users proprietary software, Adapted to cell culture or other experiments involving resistance variations: the algorithm adjusts its model to the setup resistance in real-time, Save precious sample or reagent: reduced time to reach desired flow rates uses less liquid during a calibration step, Save time with reduced settling time and no calibration. Combine up to 12 modules as your work flow grows. Pressure modules (positive pressure, negative pressure, or push-pull modules), microfluidic valve modules, and flow sensors are directly connected to the main platform. Control without a PC using the Flow EZ hardware interface with one hand. This technology can be integrated in any custom project. Prof. Jeroen Lammertyn, KU Leuven Belgium Biosensors group. This technology combines electronic and pneumatic elements engineered together with well established Fluigent regulation algorithms and knowledge. Integrated flow control: To switch from pressure control to flow rate control, one can directly add a flow sensor from our industrial FS series to the F-OEM without the need of an additional board. The pressure automatically adjusts in the background to maintain the flow rate. Our innovative pressure-based microfluidic controllers are compatible with lab on a chip device and a wide variety of microfluidic technologies that will allow you to focus on the science, not on the setup. Select modules you need and combine them together. It can easily be connected to other microfluidic devices such as FLOW UNIT sensors to allow for flow-rate control. By providing two pressure sources (any vacuum or pressurefrom -800 to +2000 mbar), each module is able to deliver one of the two provided pressures through8 independent outlets. If you are seeking to replace high-precision syringe pumps or other conventional instruments, we offer modern microfluidic systems and components that enhance productivity.. ThePXmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution. Range available from -800 mbar for vacuum aspiration and up to 7 bar for pressure. Combined with a FLOW UNIT it allows for direct control of flow rate.

Conventional water monitoring is based on laboratory instruments that are generally sophisticated and expensive. The F-OEM makes use of the best combination of pneumatic, mechanical, and electrical elements associated with our new generation algorithm: Fluigent Direct Flow-rate Control (DFC) a self-learning algorithm that performs continuous adjustment over the algorithm parameters based on the actual response time. It provides flexibility without compromising performance (accuracy and response time). Based on the patented FASTABTM technology, our pressure and flow controllers ensure a stable and pulseless flow to enhance accuracy and reproducibility in the experiments. 6). Biotechnol. This allows the user to set a flow rate directly on the instrument display. The field-proven technology ensures to obtain quickly reliable and superior results for your experiments. Each module is a separate and independant pressure channel. The Flow EZ range of modules allow for regulatation of pressure / vacuum down to -800 mbar and up to 7 bar. How to set the Flow EZ (power and pressure supply), Fluidic and pneumatic connection to the microfluidic setup, Extend the pressure system by adding modules, How to send and apply an order to pressurize a reservoir, How to disconnect a module to modify the pressure system, Add a flow sensor to control directly in flow rate, Switch the module OFF and stop the experiment, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, A human BBB (blood brain barrier)-on-chip to assess vascular permeability, Doing PhD with Fluigent 2021: Research on Honey by Daniel Kraus (Jena, Germany), Hans-Knll-Institut, New Antibiotics, Cultivation in Droplets, Microfluidic white paper An exploration of Microfluidics and fluid handling, LineUp Series, the new generation of microfluidic controllers, The Hebrew University: Single-cell encapsulation and culture in 3D hydrogels followed by InDrops / Drop-Seq microfluidic protocols for RNA profiling, University of Cambridge: Giant unilamellar vesicle production and testing, The Micro/Nano Bioelectronics and Biosensors (MBIOS) from Tianjin University, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, E. Coli culture in droplets using dSURF fluorosurfactant, Characterization of copper electrodeposition in liquid phase electron microscopy, Production of water-in-oil emulsions using a droplet generator chip, Droplet generation using syringe pumps and pressure-based flow controllers, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, University of Maryland: A soft robotic hand with integrated fluidic circuitry that can play Nintendo, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, 0,1% on the measured value (effective beyond 10% of the maximum pressure), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. Fig 1: (left) A pressure supply and pressure controller vs our new technology (right) Fluigent engineered technology. It offers excellent performance. Control and handle the fluid on the chip without additional tubing. The Fluigent LineUp series, including the new push-pull pump, enables precise and highly controlled aspiration and respiration of liquids. Connect the outlets of the P-SWITCH to independent reservoirs to perform independent injections. Fluigent has developed (patent pending) an all-in-one, free standing, compact, integrated pressure-based control with an internal pressure supply technology. Focus on the experiment instead of looking at the PC. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. Excellent response time, pulseless and highly stable, Configurable with pressure and switch control modules, Standalone platform adapted to industrial uses. This allows to perform operations that require fast response time, or require fast change between applied positive pressure and vacuum. Fluigents unique broad range of solutions for use in microfluidic and nanofluidics applications ensure full control of flow rates with a greater control, automation, precision, ease of use and also minimize contamination. Single gateway for industrial-grade microfluidic control: The platform can be used to control a pressure source and power other third-party devices required in the microfluidic system. For point-of-care applications, a touch screen can be developed based on your needs. There are many advantages to direct control: Configuration 1: 2 pressure modules. In addition, a microfluidic pressure pump can easily be integrated into a setup with the Software Development Kit (SDK). Fluigents broad range of solutions for use in microfluidic and nanofluidic applications offer greater control, automation, precision, and ease of use. No switch modules. Weighing in less than 170 g and with a volume of 140 cm3, Excellent stability and response time thanks to Fluigent pressure and liquid handling expertise. Point of care devices needing a small footprint can have engineering challenges. Users can output values for custom software applications using theSoftware Development Kit. Fluigents i (patent pending) powerful pressure regulation algorithm is based on physical equations and self-learning routines that offer several benefits: By directly connecting a flow rate sensor, it is possible to monitor or control flow rate in real time. For flow-rate monitoring and control. It provides the best response time, pulseless, and highly stable flow conditions for high precision industrial microfluidic applications. Pulse-free flow is critical for generating high quality and repeatable results.

It can be used without a PC or controlled with Fluigent Software Solutions to benefit from control in real-time, protocol automation, graphic displays and custom integration. The delivered software package is suitable for Windows and Linux platforms. The MFCS series products are well adapted to the manipulation of fluid volumes in the low to sub microliter per minute range. We offer best-in-class standard & custom OEM components, system development, and engineering services, with strong expertise in fluid management to accelerate your development process. The compact device stands near the microfluidic device, allowing the user to minimize bench space use without the need of a PC. In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. Each module is a separate and independent pressure channel. The addition of aflow sensorenables one tocontrol or monitor flow rateas well asdispense volume. Pressurize up to 32 reservoirs simultaneously or independently. The platform allows one to choose the number of pressure modules (with different ranges, if required), valve modules, and flow sensors. It is a standalone, modular platform that will perform complex fluidic operations. With the use of pressure instead of mechanical action, the Flow EZTMgets a responsiveness ten times faster than syringe pumps.

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